What is Ketoconazole?
Ketoconazole is used for the treatment of serious fungal infections. It may also be used against some yeast and dermatophyte (ringworm) infections.
Who is it for?
Dogs, birds, reptiles, ferrets, rabbits, and other small mammals. The use of Ketoconazole in cats is controversial because of its potential for toxicity in that species.
What are the benefits?
||Treats internal and external fungal infections
||Also useful in the treatment of some yeast and ringworm infections and Cushing's Disease (hyperadrenocorticism)
How does Ketoconazole work?
It is believed that Ketoconazole works on the cell membrane of the fungus or yeast to slow their growth or to kill them. It can also block the production of corticosteroids by the adrenal gland, which is the reason it may be used to treat Cushing's disease.
Is there a generic equivalent available?
How is it given?
Ketoconazole is given orally. If you have difficulty giving the medication, contact your veterinarian. This medication should only be given to the pet for which it was prescribed.
What results can I expect?
It generally takes a number of weeks to effectively treat a fungal or yeast infection, however some improvement may be seen in 1-2 weeks. If doses are missed or the entire treatment regimen is not completed, symptoms could recur or worsen, even if your pet appears to feel better. Consult your veterinarian if the animal's condition does not improve or worsens after beginning treatment with Ketoconazole.
What form(s) does it come in?
Common Drug Name
What should I discuss with my veterinarian while considering Ketoconazole?
Talk to your veterinarian about what type of outcome is expected. Have your veterinarian explain the other treatment options that may be available to treat your pet's condition.
Tell your veterinarian if your pet has liver disease or blood disease, or may be pregnant or used for breeding.
Notify your veterinarian of any other medications or supplements your pet is taking. Also if your pet has had any reactions to previous medications.
What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.
What is the most important information I should know?
Follow your veterinarian's directions and give the full course of Ketoconazole as prescribed. Consult your veterinarian if the animal's condition does not improve or worsens after beginning treatment with Ketoconazole.
Who should not take it?
Ketoconazole is not for use in animals hypersensitive (allergic) to it. Not for use in pregnant or lactating animals (female animals nursing their young) and may cause infertility in males. Ketoconazole is also for use in animals with liver disease or clotting problems.
What side effects may be seen when taking Ketoconazole?
May see lack of appetite, vomiting, diarrhea, or liver toxicity (jaundice - yellowing of gums, skin or eyes) or bleeding problems. Consult your veterinarian if you notice any of these.
May see a reversible lightening of the haircoat.
Signs of an allergic reaction may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
How is it stored?
Store in a tight, light-resistant, childproof container at room temperature. Keep out of reach of children and pets.
What should I do if I know of or suspect there has been an overdose?
If you know or suspect your pet has had an overdose, contact your veterinarian immediately.
What should I avoid when giving my pet Ketoconazole?
Consult your veterinarian before using Ketoconazole with any other medications, including vitamins and supplements, antacids, antidepressants, Mitotane, cisapride, astemizole, terfenadine, digoxin, warfarin or other anticoagulants, hypoglycemic agents, theophylline, cyclosporine, corticosteroids, and many others since interactions may occur.
Do not give with antacids or other products that alkalinize the stomach pH level. If needed, these products may be given 2 hours after the Ketoconazole dose.
Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the
Patient Information Sheet on this medication.