What is Clomicalm?
Clomicalm is a prescription medication used to treat behavior problems such as separation anxiety.

Who is it for?
Clomicalm is for dogs over 6 months of age.

What are the benefits?

How does Clomicalm work?
Clomicalm is a tricyclic antidepressant that affects the levels of certain chemicals in the brain, primarily serotonin.

Is there a generic equivalent available?
Clomipramine is the generic equivalent of Clomicalm.

How is it given?
Unless otherwise directed, give Clomicalm with food to help decrease the risk of gastrointestinal side effects. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.

This medication should only be given to the pet for whom it was prescribed.

What results can I expect?
Clomicalm can be useful in helping to correct certain behavior problems, but needs to be used along with behavior modification methods to change the behavior. It may take several weeks before any effects are observed.

What form(s) does it come in?
Clomicalm comes in tablet form.

Brand Name
Clomicalm

Pronunciation
KLOE-mi-calm

Common Drug Name
Clomipramine

What should I discuss with my veterinarian while considering Clomicalm?
Talk to your veterinarian, in detail, about the behavior modification techniques you should use in conjunction with Clomicalm. Have your veterinarian explain the other treatment options that may be available to treat your pet's condition.

Tell your veterinarian if your dog is a male and used for breeding or if your dog has had seizures.

Notify your veterinarian of any other medications or supplements your pet is receiving, especially selegiline (L-deprenyl, Anipryl), or amitraz (Preventic collars or Mitaban dip). Also tell your veterinarian if your pet has had any reactions to previous medications.

What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.

What is the most important information I should know?
To be effective, Clomicalm needs to be used in conjunction with behavior modification methods that will help your pet change the unwanted behavior. Overdoses can be very toxic, so keep Clomicalm out of the reach of children and pets.

Who should not take it?
Not for use in animals hypersensitive (allergic) to Clomicalm or other tricyclic antidepressants, such as amitriptyline.

Use with caution in animals with epilepsy, seizures, urine retention (problems urinating), decreased stomach/intestinal motility, constipation, liver or kidney disease, heart rhythm disturbances, thyroid disease, or glaucoma.

The safety of the drug has not been determined in pregnant, or lactating dogs and cats (female animals nursing their young). Do not use in males used for breeding.

Do not use in animals who are being treated, or have recently been treated with selegiline (L-deprenyl, Anipryl) or amitraz (Preventic collars or Mitaban dip).

What side effects may be seen when taking Clomicalm?
May see lack of appetite, vomiting, increased appetite and weight gain, diarrhea, lethargy, sleepiness, dry mouth, difficulty urinating, or increased heart rate. Contact your veterinarian if these side effects are severe or persistent.

If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

How is it stored?
Store at room temperature in a tightly-closed container. Keep out of reach of children and pets.

What should I do if I know of or suspect there has been an overdose?
Should overdose occur, your pet may have life-threatening reactions, such as seizures, heart arrhythmias, and heart failure, which may result in weakness, collapse, rapid breathing, or pale gums. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.

What should I avoid when giving my pet Clomicalm?
Consult your veterinarian before using Clomicalm with vitamins and supplements, monoamine oxidase inhibitors (MAOIs), such as selegiline (Anipryl), isoniazid, or amitraz (an ingredient in some tick collars, and in Mitaban, a treatment for mange), flea and tick collars, insulin, other antidepressant drugs, other drugs with anticholinergic effects (such as atropine), methimazole, other antithyroid drugs, fluoxetine, ketoconazole, or itraconazole, or cimetidine, since interactions may occur. Clomicalm may alter blood glucose levels. Avoid giving aged cheese to pets receiving Clomicalm. Aged cheese contains a chemical that could increase adverse side effects, since that chemical and the drug act on the same enzyme system in the body.

Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the Patient Information Sheet on this medication.