What is Lysodren?
Lysodren is a prescription medication used to treat pituitary-dependent Cushing's disease (hyperadrenocorticism). It may also be prescribed to treat some of the symptoms of some types of cancer of the adrenal glands.
Who is it for?
Lysodren is for dogs.
What are the benefits?
||Effectively treats Cushing's disease in dogs
||Can be used to ease symptoms of certain types of cancers of the adrenal glands
||Tablets are easily given within a fatty treat or food to increase absorption
How does Lysodren work?
The adrenal gland produces steroids (cortisone-like hormones) that have multiple effects in the body. In Cushing's disease and some types of tumors, too many of these steroids are produced. Lysodren acts on the adrenal gland so it produces less of these steroids.
Is there a generic equivalent available?
How is it given?
Lysodren is given orally, with food, preferably a food high in fat content to increase absorption. Carefully follow your veterinarian's directions as to how it should be given.
Lysodren is usually given at high doses for the first 1-10 days, and then the dose is lowered under the direction of the veterinarian. Your veterinarian will work with you closely to determine when the dose is changed and by how much. This medication should only be given to the pet for whom it was prescribed.
What results can I expect?
Each individual dog responds to Lysodren differently, but the goal of therapy is to decrease the symptoms related to Cushing's disease (increased thirst and appetite, poor hair coat, etc.). In most cases, the therapy needs to be continued for the life of the dog.
What form(s) does it come in?
Lysodren comes in tablet form.
Common Drug Name
What should I discuss with my veterinarian while considering Lysodren?
The treatment program is based upon the dog's response to the Lysodren, so be sure to understand what signs you should watch for, and when to contact your veterinarian. Understand what type of exams and tests will be necessary while your pet is taking Lysodren. Discuss the risks associated with the treatment and if any additional medications are necessary.
Tell your veterinarian if your dog has liver or kidney disease, diabetes, or could be pregnant.
Notify your veterinarian of any other medications or supplements your pet is taking, and also if your pet has had any reactions to previous medications.
What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.
What is the most important information I should know?
Fully understand your veterinarian's instructions and what side effects of the drug to watch for.
Wear gloves and wash your hands after giving Lysodren to your dog.
Who should not take it?
Not for use in animals hypersensitive (allergic) to it or drugs similar to it. Do not use in pregnant or lactating animals (female animals nursing their young).
Use with caution in animals with liver or kidney disease.
What side effects may be seen when taking Lysodren?
You may see lethargy, weakness, lack of appetite, vomiting, diarrhea, incoordination, or depression.
May cause liver damage, which could result in loss of appetite and jaundice (yellowing of the gums, skin, or eyes). Consult your veterinarian if you notice any of the above side effects.
As the drug becomes effective, you will notice a decrease in your pet's food and water intake, and urination.
If your pet experiences an allergic reaction to the medication, signs may include facial
swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
How is it stored?
Store at room temperature in a tight, light-resistant, childproof container. Keep out of reach of children and pets.
What should I do if I know of or suspect there has been an overdose?
The signs of overdose include loss of appetite, vomiting, diarrhea, weakness, depression, or lethargy.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
What should I avoid when giving my pet Lysodren?
Pregnant women or women trying to get pregnant should not handle this medication. Wear gloves when handling this medication. Wash hands after handling the medication. It can be very toxic.
Do not allow Lysodren to enter the environment through the soil or water. Any leftover drug should be returned to your veterinarian for disposal.
Consult your veterinarian before using with any other medications, including vitamins and supplements, prednisone, prednisolone, barbiturates, warfarin, phenobarbital, or spironolactone, since interactions may occur.
May see an increase in depressant effects if given with other central nervous system (CNS) depressants.
Starting therapy with this drug may cause a rapid change in the insulin requirement of diabetic animals.
Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the
Patient Information Sheet on this medication.