Vetoryl Caps (Trilostane)

What is Vetoryl?
Vetoryl is a prescription medication used in the treatment of hyperadrenocorticism, also known as Cushing's Disease, in dogs. Cushing's Disease is a condition where too much of the hormone cortisol is produced.

Who is it for?
Vetoryl is for dogs.

What are the benefits?

*	Promising treatment for Cushing's Disease in dogs
*	Treats both pituitary-dependent and adrenal-dependent cases
*	Fewer & less severe side-effects reported than Mitotane
*	Controls excess production of cortisol

How does Vetoryl work?
Vetoryl contains trilostane, a drug that controls the adrenal gland's excess production of cortisol, which is a hormone that regulates many body processes, and is released in increase amounts during stress.

Is there a generic equivalent available?
No.

How is it given?
Vetoryl capsules are given orally with food. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.

This medication should only be given to the pet for whom it was prescribed.

What results can I expect?
Vetoryl is not a cure for Cushing's Disease, but can help control the symptoms. Generally improvement will be seen in several weeks. Each individual dog responds to Vetoryl differently, but the goal of therapy is to decrease the symptoms related to Cushing's disease (increased thirst and appetite, poor hair coat, etc.). In most cases, the therapy needs to be continued for the life of the dog. If Vetoryl is discontinued, signs will reappear.

What form(s) does it come in?
Vetoryl comes in capsule form.

Please click on "More Information" for possible drug and food interactions with this medication.

Brand Name
Vetoryl

Pronunciation
vet-or-ill

Common Drug Name
Trilostane

What should I discuss with my veterinarian while considering Vetoryl?
The treatment program is based upon the dog's response to Vetoryl, so be sure to understand what signs you should watch for, and when to contact your veterinarian. Understand what type of exams and tests will be necessary while your pet is taking Vetoryl. Discuss the risks associated with the treatment and if any additional medications are necessary.

Tell your veterinarian if your pet has liver or kidney diseases, or may be pregnant or is nursing, or if you intend to breed your pet.

Notify your veterinarian of any other medications or supplements your pet is taking, and also if your pet has had any reactions to previous medications.

What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.

What is the most important information I should know?
Fully understand your veterinarian's instructions and what side effects of the drug to watch for.

Wash your hands after giving Vetoryl to your dog, and do not handle the medication if you are pregnant.

Who should not take it?
Not for use in animals hypersensitive (allergic) to trilostane.

Do not use in pregnant animals. The safe use of this drug has not been determined in lactating dogs (females nursing their young) or dogs intended for breeding.

Do not use in animals with primary liver disease or certain kidney diseases.

What side effects may be seen when taking Vetoryl?
You may see an unexpected decrease in appetite, vomiting, diarrhea, and lethargy. Rarely, may see more serious adverse effects including severe depression, bloody diarrhea, collapse, or other severe reactions, possibly leading to death. If you think your dog is having a reaction to Vetoryl, discontinue use and consult your veterinarian immediately.

If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

How is it stored?
Store at room temperature in a tight, light-resistant, childproof container. Keep out of reach of children and pets.

What should I do if I know of or suspect there has been an overdose?
Should overdose occur, you may see lethargy, weakness, vomiting, or collapse. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.

What should I avoid when giving my pet Vetoryl?
Human Precautions: Wear gloves and/or wash hands after use. Do not open, empty or divide capsules. Do not handle capsules if you are pregnant, or may become pregnant.

Notify your veterinarian of any other medications, including vitamins and supplements your pet is taking while your pet is receiving Vetoryl. Consult your veterinarian before using Vetoryl with ACE inhibitors such as enalapril, potassium-sparing diuretics such as spironolactone, ketoconazole, or potassium supplements since interactions may occur.

Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the Patient Information Sheet on this medication.

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