Epizyme® Powder (Generic)

What is Epizyme?
Epizyme is a supplemental powder form of pancreatic enzymes for use in pets with pancreatic enzyme deficiency (maldigestion syndrome, pancreatic insufficiency syndrome). Epizyme is a combination of lipases, amylases, and proteases, which are enzymes needed for digestion of fats, carbohydrates and proteins.

Who is it for?
Dogs and cats

What are the benefits?

*	Helps improves digestion of proteins, carbohydrates and fats in animals with pancreatic insufficiency
*	Easy to administer at meal time
*	Helps return pets to a healthy weight, since weight loss is common when the pancreas isn't functioning properly

How does Epizyme work?
Epizyme is used as a replacement therapy substituting enzymes normally produced by the pancreas that are needed to help digest and absorb fats, proteins, and carbohydrates. In pancreatic insufficiency, these enzymes are not produced in sufficient quantity.

Is there a generic equivalent available?
Pancrezyme® (Brand), Viokase (Brand)

How is it given?
Mix the powdered enzymes into your pet's food. If feeding dry food, moisten the food with warm water and then add the enzymes. Be sure to allow the enzymes time to work; usually the food and enzyme mixture is allowed to stand 15-20 minutes before feeding.

If using the tablet form, administer the tablet before the meal.

Feeding several small meals a day is usually recommended. If you have any questions regarding how to use this medication, contact your veterinarian.

Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.

What results can I expect?
The animal's digestion will improve immediately, though it may take some time for the animal's weight, stools, haircoat, etc. to return to normal. In most cases, Epizyme needs to be given for the life of the animal.

What form(s) does it come in?
Powder, Tablet

Please click on "More Information" for possible drug and food interactions with this medication.

Brand Name
Epizyme

Pronunciation
EP-i-zime

Generic Drug Name
Pancreatic enzymes, pancrelipase

What should I discuss with my veterinarian while considering Epizyme?
Talk to your veterinarian about what type of outcome is expected. Have your veterinarian explain any other treatment options that may be available to treat your pet's condition.

Tell your veterinarian if your pet has any food allergies.

Notify your veterinarian of any other medications or supplements your pet is taking. Also if your pet has had any reactions to previous medications.

What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once. This medication should only be given to the pet for whom it was prescribed.

What is the most important information I should know?
Follow your veterinarian's directions. Usually Epizyme needs to be given for the entire life of the animal.

Who should not take it?
Do not use in animals hypersensitive (allergic) to pork products.

What side effects may be seen when taking Epizyme?
High doses may cause diarrhea, cramping, or vomiting. If you observe any of these reactions, contact your veterinarian immediately. May cause mouth irritation if powder is not mixed well with moistened food and allowed to stand.

If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

How is it stored?
Store in a tight, light-resistant, childproof container in a cool, dry location. Keep out or reach of children and pets.

What should I do if I know of or suspect there has been an overdose?
An overdose may cause diarrhea, vomiting, or cramping. The effects should be temporary. If you know or suspect your pet has had an overdose, or if you observe any unusual signs, symptoms, or behaviors, contact your veterinarian immediately.

What should I avoid when giving my pet Epizyme?
Consult your veterinarian before using pancreatic enzymes with any other medications, including vitamins and supplements, antacids, cimetidine, and other histamine H2 receptor antagonists (medications used to decrease stomach acid), since interactions may occur. Avoid antacids since they may decrease the effectiveness of pancreatic enzymes.

Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the Patient Information Sheet on this medication.

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