What is Proin?
Proin is a prescription medication used in the management of urinary incontinence in dogs.
Who is it for?
Proin is for dogs.
What are the benefits?
An effective prescription approach to help manage urinary incontinence in dogs
Ideal solution for dogs who "dribble" on their beds or other places due to incontinence
Helps tighten the urethral sphincter, which helps to control urine leakage
How does Proin work?
Proin contains the active ingredient phenylpropanolamine, which works by tightening the bladder sphincter muscle to help control urine leakage.
How is it given?
Proin tablets are given with food. Give Proin exactly as directed by the veterinarian. If you do not understand the directions, ask the pharmacist or veterinarian to explain them to you.
What results can I expect?
Proin will not cure the incontinence, but will help manage it. It may take several days of treatment to see the full effect of the medication. To remain effective, Proin must be given continually. Stopping treatment will cause recurrence of the symptoms.
What form(s) does it come in?
Proin comes in chewable tablets and oral drops.
Please click on "More Information" for possible drug and food interactions with this medication.
Common Drug Name
What should I discuss with my veterinarian while considering Proin?
Talk to your veterinarian about what type of outcome is expected. Have your veterinarian explain the other treatment options that may be available to treat your pet's condition.
Tell your veterinarian if your pet has glaucoma, enlarged prostate, hyperthyroidism, diabetes mellitus, heart problems, high blood pressure; is pregnant; or if you intend to breed your pet.
Notify your veterinarian of any other medications or supplements your pet is taking. Also tell your veterinarian if your pet has had any reactions to previous medications.
What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.
What is the most important information I should know?
Give Proin exactly as your veterinarian prescribes. Missed doses could result in a recurrence of symptoms.
Contact your veterinarian if your pet becomes restless, irritable or the incontinence persists or gets worse.
Who should not take it?
Not for use in animals hypersensitive (allergic) to it. Do not use in animals with glaucoma, enlarged prostate, hyperthyroidism, diabetes mellitus, heart problems, or high blood pressure.
Do not use in pregnant, or lactating animals (female animals nursing their young).
What side effects may be seen when taking Proin?
May see restlessness or irritability. You may also see increased heart rate, increased blood pressure, or loss of appetite. If you see any of these signs, or the incontinence persists or worsens, contact your veterinarian.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives,
scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
How is it stored?
Store Proin at room temperature away from moisture and heat. Keep this medication away from children and pets.
What should I do if I know of or suspect there has been an overdose?
Should overdose occur, you may see loss of appetite, lethargy, increased blood pressure, increased heart rate, weakness, collapse, rapid respiration, pale gums, heart failure, seizures, or coma.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
What should I avoid when giving my pet Proin?
Consult your veterinarian before using Proin with any other medications, including vitamins and
supplements, ephedrine, epinephrine, or beta-blockers (like propranolol), since interactions may occur.
Do not use with or within 2-5 weeks of using monoamine oxidase inhibitors (MAOIs) such as selegiline
(deprenyl, Anipryl), isoniazid, or amitraz (an ingredient in some flea collars and in Mitaban, used to treat
mange). Consult your veterinarian before using other medications or tick collars along with Proin.
There is an increased risk of high blood pressure if used with non-steroidal anti-inflammatory (NSAID) drugs (e.g., aspirin, carprofen (Novox or Rimadyl), etodolac (EtoGesic), meloxicam (Metacam), firocoxib
(Previcox), deracoxib (Deramaxx), tepoxalin (Zubrin) or tricyclic antidepressants (e.g., amitriptyline or
clomipramine). There is also an increased risk of irregular heart rhythms if used with digoxin.
Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the
Patient Information Sheet on this medication.
Older dogs can experience many changes in the functions of their bodies. Some dogs may have more pronounced changes than others, and in some dogs, the changes may start to occur at a younger age. Knowing what changes to expect can help. Learn more.
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