Synotic ^® Otic Solution (Brand)

What is Synotic?
Synotic is a topical corticosteroid with DMSO used in the treatment of inflammation and itching of the ear.

Who is it for?
Synotic is labeled for use in dogs.

What are the benefits?

This topical medication is used in the treatment of certain inflammatory conditions of the ear. It contains the corticosteroid fluocinolone, an anti-inflammatory medication. It also includes DMSO, which enhances the absorption of the fluocinolone and has anti-inflammatory properties. Comes in a convenient dropper bottle.

How does Synotic work?
Synotic works by blocking the production of substances that trigger allergic and inflammatory responses in the ear.

Is there a generic equivalent available?
No.

How is it given?
Synotic is given topically. The ear should be thoroughly cleaned and dried before treatment. Remove any debris, crusty material, etc., with a suitable non-irritating ear cleaning solution. Clip any excessive hair from the ear or treatment area, as directed.

Apply the prescribed amount in the ear and gently massage the ear to distribute the medication. Avoid contact with the eyes. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.

Wear gloves when applying Synotic. Avoid contact with your bare skin. The DMSO is rapidly absorbed through the skin, enters the blood stream, and causes an unpleasant taste in the mouth for a short time. Avoid contact with the treated area until it has dried.

Do NOT give Synotic by mouth.

What results can I expect?
The anti-itching component of Synotic occurs quite rapidly (within hours). The anti-inflammatory effect may take longer.

What form(s) does it come in?
This medication comes in liquid form, with a convenient dropper bottle for topical application.

Please click on "More Information" for possible drug and food interactions with this medication.

Pronunciation
Sin-OH-tick

Common Drug Name
Fluocinolone with dimethyl sulfoxide (DMSO)

What should I discuss with my veterinarian while considering Synotic?
If Synotic is to be used in the ear, your veterinarian should examine your pet's ear to make sure the ear drum is intact. Have your veterinarian or veterinary technician show you how to properly clean the ear and apply Synotic.

Have your veterinarian explain what results you can expect and when to call if improvement in the condition is not seen.

Notify your veterinarian of any other medications or supplements your dog is taking, and also if your dog has had any reactions to previous medications. Also tell your veterinarian if your pet is pregnant or nursing.

What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.

What is the most important information I should know?
Wear gloves when applying Synotic. Avoid contact with eyes.

The DMSO in Synotic may increase the absorption of other drugs. Be sure to tell your veterinarian if your pet is taking other medications.

Who should not take it?
Not for use in animals hypersensitive (allergic) to fluocinolone or DMSO. Do not use in pregnant animals unless the benefits outweigh the risks.

This medication should only be given to the pet for which it was prescribed.

What side effects may be seen when taking Synotic?
DMSO may cause a garlic or oyster-like breath and taste in the mouth. Corticosteroids with DMSO may cause a short, stinging sensation, especially on open skin, and a temporary increase in temperature of the treated area may be noticed.

If ingested or given at high doses for an extended period of time, the most common side effect of corticosteroids with DMSO is an increase in the amount of drinking and urinating. Less commonly, you may see an increased appetite, a change in weight, panting, diarrhea, vomiting, and behavior changes. Consult your veterinarian if you notice any of the above side effects.

If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

How is it stored?
Store Synotic at room temperature in a tight, light-resistant, childproof container. Keep out of the reach of children and pets.

What should I do if I know of or suspect there has been an overdose?
You may see an increase in the amount of drinking and urinating; loss of weight; panting; diarrhea and vomiting; or behavior changes. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.

What should I avoid when giving my pet Synotic?
Contact your veterinarian before using Synotic with vitamins and supplements, or in the presence of other medications, non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, carprofen (Rimadyl), deracoxib (Deramaxx), or etodolac (EtoGesic), since interactions may occur.

Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the Patient Information Sheet on this medication.