Acepromazine (Generic)

What is Acepromazine?
Acepromazine is a prescription tranquilizer. Acepromazine is used to sedate animals for minor procedures (e.g., nail trims) and has also been used to prevent vomiting due to motion sickness. It is also used prior to anesthesia as a pre-anesthetic.

Who is it for?
Acepromazine is labeled for use in dogs, but may be used off-label in other species.

What are the benefits?

*	Prescription tranquilizer sedates animals for minor procedures including nail trims
*	May be used prior to anesthesia
*	Acepromazine tablets are available in two prescription strengths for accurate dosing

Acepromazine is used to sedate animals for minor procedures (e.g., nail trims) and has been used to prevent vomiting due to motion sickness. It is also used prior to anesthesia. It does not provide any analgesia (pain relief).

How does Acepromazine work?
Acepromazine is a tranquilizer that depresses certain activity of the central nervous system and causes sedation and muscle relaxation.

Is there a generic equivalent available?
Acepromazine is a generic medication.

How is it given?
Acepromazine tablets are given by mouth. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. This medication should only be given to the pet for whom it was prescribed.

What results can I expect?
Oral acepromazine will not reach its maximum effective level until approximately one hour after administration. The effect may last up to 12 hours. The effects vary markedly among dog breeds. Collies, Australian shepherds, greyhounds and giant breeds may be more sensitive to this medication.

What form(s) does it come in?
Acepromazine is available in tablet or injectable liquid form.

Please click on "More Information" for possible drug and food interactions with this medication.

Brand Name
PromAce

Pronunciation
Ace-pro-MA-zeen

Common Drug Name
Acepromazine

What should I discuss with my veterinarian while considering Acepromazine?
Talk to your veterinarian about what type of outcome is expected. Have your veterinarian explain the other treatment options that may be available.

Tell your veterinarian if your pet has liver or heart disease or any aggressive tendencies.

Notify your veterinarian of any other medications or supplements your pet is taking. Also if your pet has had any reactions to previous medications.

What should I do if I miss a dose?
In most cases, only one dose of Acepromazine is needed. If multiple doses are prescribed, if you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.

What is the most important information I should know?
Acepromazine should be used with caution in aggressive animals, as it can make their behavior unpredictable. Acepromazine may color the urine pink or reddish brown-don't let this alarm you. Acepromazine has no pain-relieving properties.

Who should not take it?
Not for use in animals hypersensitive (allergic) to it or other phenothiazines. Use with caution in debilitated or geriatric animals and those with liver or heart disease. Do not use in pregnant or lactating animals (female animals nursing their young) unless benefits outweigh the risks. Do not use in animals with hypovolemia (low blood volume), anemia, or shock. Do not use in animals with tetanus or strychnine toxicity. May cause seizures. Do not use with animals known to have seizures or are having medical procedures known to cause seizures (e.g., myelograms).

What side effects may be seen when taking Acepromazine?
May see droopy eyelids with the third eyelid more exposed, incoordination, or slower heart rate and breathing. Urine may appear pink or reddish brown following use of acepromazine. May cause aggressiveness and stimulation in some animals. Causes low blood pressure and inability to maintain proper body temperature.

How is it stored?
Store in a tight, light-resistant, childproof container at room temperature. Protect the injectable liquid from freezing. Keep out of reach of children and pets.

What should I do if I know of or suspect there has been an overdose?
If you know or suspect your pet has had an overdose, contact your veterinarian immediately.

What should I avoid when giving my pet Acepromazine?
Consult your veterinarian before using Acepromazine with vitamins, supplements, atropine, central nervous system (CNS) depressant drugs (such as barbiturates, narcotics, and antidepressants), organophosphate dewormers or insecticides, Kaopectate, Pepto-Bismol, other antidiarrheal mixtures, antacids, propranolol, quinidine, phenytoin, and epinephrine. Acepromazine is an inappropriate medication for the treatment of aggression since it can make aggressive animals less predictable, and can interfere with training.

Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the Patient Information Sheet on this medication.

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