Thank you for your question. To mix the Goat's Milk Esbilac Powder, gently stir or shake one part powered Goat's Milk Esbilac Powder into two parts warm water (a part is a teaspoon, tablespoon or cup). Do not mix more Goat's Milk Esbilac Powder than can be consumed in 24 hours. Do not use a blender. It is recommended Goat's Milk Esbilac should be kept refrigerated. Feed puppies 2 tablespoons (30mL) liquid per 4 ounces (115g) of body weight daily. The daily feeding rate should be divided into equal portions for each feeding. Puppies' needs will vary and this amount may have to be increased or decreased, depending on the individual. Young and/or weak puppies should be fed every 3 to 4 hours.