Misoprostol (Generic) Tablets

What is Misoprostol?
Misoprostol is used for the treatment and prevention of stomach ulcers in dogs. It is used to treat stomach ulcers, especially those due to the use of non-steroidal anti-inflammatory drugs such as aspirin, etodolac (EtoGesic), deracoxib (Deramaxx), and carprofen (Rimadyl).

Who is it for?
Misoprostol is for dogs.

What are the benefits?

*	Prescription medication for the treatment and prevention of stomach ulcers
*	Misoprostol treats stomach ulcers by decreasing stomach acid formation
*	Provides treatment for stomach ulcers commonly associated with NSAID use

Misoprostol is a prescription medication for the treatment and prevention of stomach ulcers. It is used to treat stomach ulcers in dogs, especially those due to the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, etodolac (EtoGesic), deracoxib (Deramaxx), and carprofen (Rimadyl). Misoprostol is also used to decrease the toxic effects to the kidney resulting from the use of cyclosporine.

How does Misoprostol work?
Misoprostol treats and prevents gastric (stomach) ulcers by protecting the stomach lining and decreasing stomach acid formation. Misoprostol is a synthetic form of a prostaglandin.

Is there a generic equivalent available?
Misoprostol is a generic medication.

How is it given?
Misoprostol is given by mouth. May be given with small amount of food if stomach upset occurs. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.

This medication should only be given to the pet for whom it was prescribed.

What results can I expect?
Misoprostol acts rapidly to reduce stomach acid, but the effectiveness is short-lived so doses must be given more than once a day. Although it acts rapidly, a stomach ulcer can take a long time to heal.

What form(s) does it come in?
Tablet

Please click on "More Information" for possible drug and food interactions with this medication.

Brand Name
Cytotec

Pronunciation
My-so-PRAH-stole

Common Drug Name
Misoprostol

What should I discuss with my veterinarian while considering Misoprostol?
Talk to your veterinarian about what type of outcome is expected. Have your veterinarian explain the other treatment options that may be necessary to treat or prevent stomach ulcers in your pet.

Tell your veterinarian if your pet has a history of seizures, heart disease, or is pregnant, could be pregnant, or is nursing puppies.

Notify your veterinarian of any other medications or supplements your pet is taking and also if your pet has had any reactions to previous medications.

What should I do if I miss a dose?
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.

What is the most important information I should know?
Misoprostol can cause abortions. Pregnant women should not handle it. If severe diarrhea or stomach upset occurs, contact your veterinarian who may need to adjust the dose.

Who should not take it?
Not for use in animals hypersensitive (allergic) to it or hypersensitive to prostaglandins. Do not use in pregnant animals, since it may cause abortion. Do not use in lactating animals (female animals nursing their young), as the puppies may develop serious diarrhea. Do not use in animals with vascular (blood vessel) disease of the brain or heart.

What side effects may be seen when taking Misoprostol?
May see diarrhea, abdominal pain, vomiting, or flatulence (excess gas). May see vaginal bleeding or uterine contractions in female dogs.

How is it stored?
Store at room temperature in a tight, light-resistant, childproof container. Keep out of reach of children and pets.

What should I do if I know of or suspect there has been an overdose?
If you know or suspect your pet has had an overdose, contact your veterinarian immediately. Signs of an overdose include diarrhea, vomiting, seizures, and weakness.

What should I avoid when giving my pet Misoprostol?
Consult your veterinarian before using Misoprostol with any other medications, including vitamins and supplements and magnesium-containing antacids, since interactions may occur.

Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the Patient Information Sheet on this medication.

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