Bio Spot ® Topical for Dogs

Dosage:
One dose monthly. Toy dog dose for dogs under 15 lbs.; Small dog dose for dogs 15-33 lbs.; Large dog dose for dogs 33-66 lbs.; XLarge dog dose for dog over 66 lbs.

p_1936_additional.jpgHow To Apply:
Simply remove Bio Spot product tube with notched end pointing up and away from your face and body. Cut off narrow end at notches, invert tube over dog and use open end to part dog's hair. Squeeze tube firmly to apply all of the solution as a stripe to the dogs back between the shoulder blades, from upper back to base of tail. Repeat applications if necessary, but do not apply more often than once every 3 weeks. Re-application may be necessary after shampooing.

As veterinarians, we have always been impressed with the safety and effectiveness of pyrethrins and permethrins especially when used in combination with IGR's (insect growth regulators) which prevent flea eggs and larvae from developing. When you purchase flea and tick items, consider the safety and effectiveness of these products, as well as the cost. The ingredients in Bio Spot do not affect fertility in animals.

Pyrethrins
are one of the most widely used insecticides in today's flea and tick products and have been used as insecticides for over 100 years. Pyrethrins are natural extracts made from flowers of chrysanthemum plants. Pyrethrins affect the nervous system of insects and result in repeated and extended firings of the nerves. They do this by affecting the flow of sodium out of nerve cells. Permethrins are a stronger form of synthetic pyrethrins and could not be used on cats.

Insect growth regulators (IGRs) include methoprene (Precor), Fenoxycarb and Pyriproxyfen (Nylar). The IGRs mimic the juvenile growth hormone of fleas. The juvenile growth hormone is what keeps the fleas from developing into more mature forms. When the levels of juvenile growth hormone decrease, the larval form matures. The IGRs keep this development from occurring and the immature forms of the flea fail to molt and death occurs.

Ingredients in all Bio Spot for Dogs Topical formulas:

Permethrin (CAS #52645-53-1) 45%

Pyriproxyfen/Nylar (CAS #95737-68-1) 5%

Other ingredients 50%

Adverse Reactions
Some animals may be sensitive to ingredients in this product, which may include skin sensitivity and rash. Dogs may also show lethargy, increased pruritus (itchiness), erythema (redness), rash and hair discoloration or hair loss at the application site. Observe the dog following treatment. Sensitivity may occur after using ANY pesticide product on pets. If signs of sensitivity occur, bathe your dog with a mild, non-insecticidal shampoo and rinse with large amounts of water. If signs continue, consult a veterinarian immediately.

Storage and Disposal
Do not contaminate water, food, or feed by storage or disposal. Storage: Store in a cool, dry place. Protect from freezing. Pesticide Disposal: securely wrap original container in several layers of newspaper and discard in trash. Container disposal: Do not reuse empty container. Wrap container and put in trash.

What is the life cycle of fleas?

The four stages in the development of fleas include: eggs, larvae, pupae and adults. Male and female fleas mate and two days later the female flea starts laying eggs. The eggs are often laid on the animal, but because they are not sticky, fall off into the environment. Along with the eggs, the female flea deposits a large amount of feces (often called "flea dirt"). The feces called flea dirt will dissolve into a red color when moistened; this is because it is composed primarily of digested blood. The flea lays 30-50 eggs per day, generally in batches of 3 to 15. A flea can produce 400-1,000 eggs in her lifetime (several months to two years, depending on the species).

Two days (or more depending on temperature) after the egg is laid it hatches and the larva, which looks like a tiny maggot, starts to feed on the feces left by its mother. During the next seven days, the larva passes through several phases of development. At that time the larva starts spinning a cocoon and becomes a pupa. The cocoon is sticky, will often become covered with fine dirt or sand, and can be found deep in carpet or crevices. In a week, the pupa develops into an adult and emerges from the cocoon when it senses vibrations, carbon dioxide, or warmth (which tells it an animal host is near). The entire life cycle takes about 15 days, but the pupa can remain dormant under inhospitable conditions (e.g., cold) and extend the cycle to over a year. This is important to remember when planning flea control.

What is the life cycle of ticks?

Most ticks are what we call three host ticks, that is, during their development, which takes two years, they feed on three different hosts. All ticks have four stages to their life cycle: egg, larva (seed tick), nymph, and adult. Let's look at the life cycle of the deer tick as an example. The deer tick is the vector, or the transmitter, of the organism that causes Lyme Disease. Adult female deer ticks lay eggs on the ground in spring. Later in the summer (depending on moisture and temperature), the eggs hatch into larvae. The larvae, which are smaller than the period at the end of this sentence, find an animal (the first host, which is usually a bird or rodent), live off its blood for several days, then detach and fall back onto the ground. For deer ticks, this most commonly occurs in the month of August. In the ground, the well-fed larvae now molt into the next stage and are called nymphs. The nymphs remain inactive during the winter months and in spring become active. The nymph now finds an animal (the second host - a rodent, pet or human) and feeds again. Once well fed, the nymph detaches and falls back to the ground. Here it molts and changes into an adult. Throughout the fall, both adult male and female ticks now find another animal (the third host - a rodent, deer, pet, or human), feed on blood, and mate. Once well fed, both males and females fall back to the ground. The male now dies and the female survives over winter and lays eggs in the spring, completing the cycle.

Individual Sensitivities:
Some animals may be sensitive to ingredients in this product. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. As with any product consult your veterinarian before using on medicated, debilitated, aged, pregnant or nursing animals.

Cats which groom or have close physical contact with recently treated dogs may be at risk of serious harmful side effects.

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